SEC14L2

Identifiers Symbols SEC14L2; C22orf6; SPF; TAP; TAP1 External IDs OMIM: 607558 MGI: 1915065 HomoloGene: 8245 GeneCards: SEC14L2 Gene

Gene Ontology
Molecular function	• transporter activity • phospholipid binding • vitamin E binding
Cellular component	• nucleus • cytoplasm • integral to membrane
Biological process	• transcription, DNA-dependent • regulation of cholesterol biosynthetic process • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23541 67815 Ensembl ENSG00000100003 ENSMUSG00000003585 UniProt O76054 Q99J08 RefSeq (mRNA) NM_001204204 NM_144520 RefSeq (protein) NP_001191133 NP_653103 Location (UCSC) Chr 22:
30.79 – 30.82 Mb Chr 11:
4.1 – 4.12 Mb PubMed search

SEC14-like protein 2 is a protein that in humans is encoded by the SEC14L2 gene.

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway.