Cause
The causes of seborrheic keratosis are unclear. Because seborrheic keratoses are common on sun exposed areas such as the back, arms, face, and neck, ultraviolet light may play a role, as may genetics. However, they are also found on skin that has not been exposed to the sun. A mutation of a gene coding for a growth factor receptor, (FGFR3), has been associated with seborrheic keratosis.
Although no direct cause-effect relationship between physiological stress and tumors in general has been medically established, medically, stress is recognized as a potential factor in the exacerbation of preexisting tumors, including those which are benign. Therefore, physiological stress has the potential to worsen a preexisting condition such as seborrheic keratosis.
Seborrheic keratosis also may be one of the many symptoms of gastrointestinal malignancies.
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