Sebaceous Gland - Pathology

Pathology

Sebaceous glands are involved in skin problems such as acne and keratosis pilaris. In the skin pores, sebum and keratin can create a hyperkeratotic plug called a "microcomedone". The prescription drug isotretinoin significantly reduces the amount of sebum produced by the sebaceous glands, and is used to treat acne.

The extreme use (up to 10 times doctor-prescribed amounts) of anabolic steroids by bodybuilders, for muscle gain can cause acne. The sebaceous gland is stimulated due to some steroids conversion into dihydrotestosterone. This may cause serious acne on the face, neck, chest, back and shoulders.

It is a common misconception that a blocked sebaceous gland is known as a sebaceous cyst. Cysts that are commonly called sebaceous cysts actually do not involve a sebaceous gland. Instead, they are collection of dead keratinocytes which develop within the epidermal skin layer. These cysts are called Epidermal Cysts.

A condition involving enlarged sebaceous glands is known as sebaceous hyperplasia.

Sebaceous gland carcinoma is a rare and aggressive form of cancer involving the sebaceous glands; sebaceous adenoma is a more benign neoplasm of the sebaceous glands.

Sebum can also build up around body piercings.

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