Technology, Science, and Manufacturing
- Structural Engineer, (abbreviated "S.E."), a post-nominal suffix indicating license by a government entity to practice Structural Engineering
- Single-ended (disambiguation)
- Single-ended signalling, a method used in the SCSI standard
- Software engineering
- Systems Engineering
- Macintosh SE "System Expansion", a personal computer manufactured by Apple
- SE Electronics, a microphone manufacturer based in Shanghai
- Slovenské elektrárne, the state electricity company of Slovakia
- Mercedes-Benz SE, "Sonderklasse Einspritzung" (Special or Super Class Fuel Injected) automobile, see Mercedes-Benz W108
- Sony Ericsson, a mobile phone company formed by Sony and Ericsson
- Square Enix, a video game company
- Ferrocarriles Unidos del Sureste reporting mark
- Super Extra, in relation with a car body style
- SE, IATA airline designator for XL Airways France (formerly "Star Airlines")
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