Scalene may refer to:
- A scalene triangle, one in which all sides (and therefore angles) are different
- A scalene ellipsoid, one in which the lengths of all three semi-principal axes are different
- Scalene muscles of the neck
- Scalene tubercle, a slight ridge on the first rib prolonged internally into a tubercle
- Scalene, a 2011 independent film directed by Zack Parker