Scaife is a surname, and may refer to:
- Brendan Scaife (b. 1928), Irish Academic Engineer and Physicist
- Bo Scaife (b. 1981), American professional football player
- Bobby Scaife (b. 1955), English professional football player
- Cordelia Scaife May (1928–2005), American wealthy philanthropist; sister of Richard Mellon Scaife
- Richard Mellon Scaife (b. 1932), American newspaper publisher; heir to the Mellon fortune
- Ross Scaife (1960–2008), American academic and scholar
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