SC-6 or variant may refer to:
- South Carolina's 6th congressional district
- SC 6, an abbreviation for South Carolina Highway 6
- Strathcarron SC-6, a British sports car; see Strathcarron Sports Cars
- USS SC-6, a United States Navy submarine chaser commissioned in 1918 and sold in 1921
- SC06, a FIPS 10-4 region code, see List of FIPS region codes (S–U)
- SC-06, a subdivision code for the Seychelles, see ISO 3166-2:SC