Sayre may refer to
People:
- David Austin Sayre (1793-1870), American silversmith, banker, and educator
- Francis B. Sayre (1885-1972), American ambassador and son-in-law of President Woodrow Wilson
- Francis B. Sayre, Jr. (1915-2008), Episcopal cleric and Dean of Washington Cathedral
- Geoffrey Sayre-McCord (born 1956), American philosopher
- James Willis Sayre (1877-1963), American theatre critic
- Lewis Albert Sayre (1820-1900), American orthopedic surgeon
- Nora Sayre (1932-2001), American film critic
- Robert H. Sayre (1824-1907), American businessman
- Stephen Sayre (1736-1818), American revolutionary who allegedly planned to kidnap George III
- Zelda Sayre (1900-1948), American novelist and wife of writer F. Scott Fitzgerald
Places:
- Sayre, Oklahoma, a town in Beckham County, Oklahoma, United States
- Sayre, Pennsylvania, a borough in Bradford County, Pennsylvania, United States