Sasuke may refer to:
In History and Geography
- Sasuke Inari Shrine, a Shinto Shrine in Kamakura, Japan
In general usage:
- Sasuke (TV series), a televised sports entertainment special in Japan
- Sasuke (wrestler) or Masanori Murakawa (born 1969), Japanese professional wrestler
In fictional characters:
- Sasuke Uchiha, a character in Naruto media
- Sasuké (Usagi Yojimbo), a character in the Usagi Yojimbo universe
- Sasuke Sarugakure, a character in the Ranma ½ universe
- Sarutobi Sasuke, a character in Japanese children's stories
- Sasuke (Ganbare Goemon), a character in Legend of the Mystical Ninja series media
- Sasuke or NinjaRed, one of several main characters in the Ninja Sentai Kakuranger television series
- Sasuke Matsutani, a character in the Legendz universe
- Sasuke (Mirmo!) or Sazo, a character in Mirmo! media
- Sasuke, a character in Ninin Ga Shinobuden media
- Sasuke Sagami, a character in the Animal Academy: Hakobune Hakusho universe
- Sasuke a character for a video game Ninja Master's