Sarkissian / Sarkisian
- Adrian Sarkissian (born 1979), Uruguayan footballer
- Alex Sarkisian (1922–2004), American football player
- Amy Sarkisian (born 1969), artist living and working in Los Angeles, California
- Ararat Sarkissian, Armenian artist, who was born in Gyumri in 1956
- Arthur Sarkissian (born 1960), an Armenian artist and painter
- Cherilyn Sarkisian (born 1946), aka "Cher", American performer
- Karnig Sarkissian, an Armenian singer
- Margos Sarkissian character of Terminator: The Sarah Connor Chronicles
- Mark Sarkisian, American civil engineer, director of Seismic and Structural Engineering in the San Francisco office of Skidmore, Owings and Merrill
- Peter Sarkisian (born 1965), American video and multimedia artist
- Setrak Sarkissian, Lebanese Tabla player
- Steve Sarkisian (born 1974), Washington Huskies football head coach
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