Santiago Maior may refer to:
- Cape Verde:
- Santiago Maior, Cape Verde, a parish of the municipality of Santa Cruz
- Portugal:
- Santiago Maior (Alandroal), a parish in the municipality of Alandroal
- Santiago Maior (Beja), a parish in the municipality of Beja
- Santiago Maior (Castelo de Vide), a parish in the municipality of Castelo de Vide