Sanshiro may refer to:
- Plawres Sanshiro, popular anime series aired in 1983 in Japan, Hong Kong, the Middle East and Greece and Algeria
- Sanshiro Sugata, the directorial debut of the Oscar-winning Japanese film director Akira Kurosawa
- Sanshiro Sugata Part II, 1945 film written and directed by Akira Kurosawa.
- Sanshiro Takagi (born 1975), Japanese professional wrestler
- Segata Sanshiro, fictional character created by Sega to advertise the Sega Saturn in Japan between 1997 and 1998
- Sanshiro (三四郎), a novel written in 1908 by Natsume Sōseki, about changes in feelings of Japanese youth in the late Meiji Period