Sano may refer to:
- Sano, (Sanoshoes), a brand of wellness shoes produced by Mephisto of France
- Sano, Tochigi, a city in Japan
- Sano (company), an Israeli manufacturer of chemical products
- Monte Sano Mountain, a mountain in Alabama, United States
- Monte Sano State Park
- Wai Sano, a volcano in Flores, Indonesia
- Mens sana in corpore sano, a quotation by Juvenal
- A defunct brand of cigarettes from United States Tobacco Company endorsed by Martin Kane, Private Eye
- Sano, Yarang - Pattani Province, Thailand
People:
- Stante, Sano, a Canadian/Italian real estate and sustainability expert
- Fusako Sano, Japanese girl abducted and held in captivity from 1990 to 2000
- Sano Nanami (b. 1979), Japanese actress
- Naoki Sano, Japanese professional wrestler
- Natsume Sano (b. 1985), Japanese actress and model
- Roy I. Sano (b. 1931), Japanese-American Methodist bishop
- Sano Tsuneha (1871–1956), Japanese Scouting notable
- Sano Tsunetami (1822–1902), founder of the Japanese Red Cross
- Yasuomi Sano (b. 1984), Japanese actor
- Yuko Sano (b. 1979), Japanese volleyball player
- Sano di Pietro (1406–1481), an early Italian Renaissance painter
- Miguel Angel Sano, Dominican baseball player
Fictional characters:
- Seiichhiro Sano, a character from The Law of Ueki
- Sano (Rurouni Kenshin) or Sagara Sanosuke, a character in Rurouni Kenshin media
- Sano Ichirō, a samurai detective from a series of mystery novels by Laura Joh Rowland
- Izumi Sano, a character from the manga series Hana-Kimi by Hisaya Nakajo
- Honoka Sano, a character from Strike Witches