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- Wilbur F. Sanders (1834–1905), American lawyer and Senator from Montana
- William David Sanders (1951–1999), American teacher and victim of Columbine High School massacre
- William Edward Sanders (1883–1917), New Zealand Victoria Cross recipient in World War I
- William J. Sanders, vertebrate paleontologist
- William P. Sanders (1833–1863), officer in the Union Army in the American Civil War
- William Sanders (businessman) (born 1941), American businessman
- William Sanders (statistician), statistician
- William Sanders (writer) (born 1942), American science fiction writer
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