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- James Sanders (American basketball player), former American basketball player, now coach
- James Sanders (American football) (born 1982), American football safety
- James Sanders Holman (1804–1867), the first mayor of Houston, Texas
- Jan Sanders van Hemessen (c. 1500–c. 1566), Northern Renaissance painter
- Jerry Sanders (businessman) (born 1936), American co-founder and long-time CEO of the American semiconductor manufacturer Advanced Micro Devices (AMD)
- Jerry Sanders (politician) (born 1950), American Republican politician, Mayor of San Diego, California, and former Chief of Police
- John E. Sanders, American evangelical Christian theologian
- John Sanders (architect), British architect of the late eighteenth century
- John Sanders (musician) (1933–2003), English musician associated with the tradition of Anglican church music
- Jon Sanders (born 1939), Australian yachtsman
- Joseph Sanders (1877-1960), German-American who helped invent the record player and helicopter, among other things
- Joseph G. Sanders, military officer in the U.S. Civil war who fought for both the Union and the Confederacy
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