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- Pat O'Malley (1890–1966), actor
- Henry O'Neill (1891–1961), actor
- Leslie O'Pace (1909–1985), actor
- Ernest Orsatti (1902–1968), major league baseball player
- Artie Ortego (1890–1960), actor
Read more about this topic: San Fernando Mission Cemetery
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Read more about this topic: San Fernando Mission Cemetery