Samu may refer to:
- SAMU, trade-name of a brand of Thai coconut water
- Samu, nickname for a Homo erectus man found in Vértesszőlős, Hungary
- SAMU - Service d'Aide Médicale d'Urgence, an emergency medical service in France.
- Servicio de Atencion Medica Urgente, also an emergency medical service
- Serviço de Atençao Medica Urgente, also an emergency medical service
- Samu, ring name of Samoan-American professional wrestler, Samula Anoa'i
- as-Samu - the Palestinian village in the West Bank
- Samu (Zen) - work that encourages mindfulness, practiced in Zen
- Samu, South Khorasan, a village in South Khorasan Province, Iran
- South African Medical Unit (SAMU) of Médecins Sans Frontières (MSF)