Sambo may refer to:
- Sambo (racial term), a racial term for a person with mixed African and Native American heritage (see zambo)
- Sambo (martial art), a martial art developed in the USSR
- Sambo from The Story of Little Black Sambo, a book
- Sambo's, a restaurant chain
- Sambo's Grave, grave of a slave (died 1736) at Sunderland Point in Lancashire, England
- TG Sambo, a Korean computer manufacturer
- Sambomaster, a Japanese rock band
- Samboende, a Swedish term for people in cohabitation
- Sambo, the name in Ecuador for cucurbita ficifolia, a type of gourd
- Sambo, a romanized term for the three ancestral treasures of Chinese culture
- Sambo, Irish and Australian slang term for sandwich