Other Salvinorins
Salvinorin A is one of several structurally related salvinorins found in the Salvia divinorum plant. Salvinorin A can be synthesized from the inactive salvinorin B by acetylation. The des-acetylated analog salvinorin B is devoid of human activity. It was speculated that salvinorin C might be even more potent than salvinorin A, but human tests and receptor binding assays could not confirm this . Salvinorin A seems to be the only active naturally occurring salvinorin.
| Name | Structure | R1 | R2 | Activity |
|---|---|---|---|---|
| Salvinorin A | -OCOCH3 | − | active | |
| Salvinorin B | -OH | − | inactive | |
| Salvinorin C | -OCOCH3 | -OCOCH3 | unknown | |
| Salvinorin D | -OH | -OCOCH3 | inactive | |
| Salvinorin E | -OCOCH3 | -OH | inactive | |
| Salvinorin F | -H | -OH | unknown |
The newly discovered salvinorin J is most closely related to salvinorin E in structure, with a C-17 secondary alcohol instead of a ketone group.
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