Sakaguchi (坂口) is a Japanese surname and may refer to:
- Alicja Sakaguchi (born 1954), a Polish linguist
- Ango Sakaguchi (1906–1955), a Japanese novelist and essayist
- Chikara Sakaguchi (born 1934), a Japanese politician
- Daisuke Sakaguchi (born 1973), a Japanese voice actor
- Hironobu Sakaguchi (born 1962), a Japanese game designer, game director and game producer
- Hiroyuki Sakaguchi (born 1965), a Japanese baseball player
- Kenji Sakaguchi (born 1975), a former Japanese football player
- Kinichiro Sakaguchi ( 1897- 1994), a Japanese agricultural chemist and microbiologist
- Kōichi Sakaguchi, a Japanese voice actor
- Seiji Sakaguchi (born 1942), a retired Japanese professional wrestler
- Shūhei Sakaguchi (born 1977), a Japanese voice actor
- Tak Sakaguchi (born 1975), a Japanese actor, director, fight choreographer and stuntman
- Yoshisada Sakaguchi (born 1939), a Japanese actor and voice actor
Fictional characters:
- Alice Sakaguchi, a Please Save My Earth character