The acronym SAIC can stand for:
- SAIC (company): A defense contractor whose initials stand for Science Applications International Corporation
- SAIC Motor, a China-based automaker formerly named Shanghai Automotive Industry Corporation
- School of the Art Institute of Chicago
- Special Agent in Charge, acronym used by some U.S. Federal agencies (F.B.I., etc.)
- South African Indian Congress
- Single antenna interference cancellation