DNA Damage
Damage to DNA is detected and fixed during S-phase. When the replication fork comes upon damaged DNA, ATR, a protein kinase, is activated. This kinase initiates several complex downstream pathways causing a halt in the initiation of new replication origins, prevention of mitosis and replication fork stabilization in order to keep the replication bubble open and DNA polymerase complex attached while the damage is being fixed.
Read more about this topic: S Phase
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