S100A10

S100A10

Identifiers Symbols S100A10; 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca; GP11; P11; p10 External IDs OMIM: 114085 MGI: 1339468 HomoloGene: 2228 ChEMBL: 1764939 GeneCards: S100A10 Gene

Gene Ontology
Molecular function	• receptor binding • calcium ion binding
Cellular component	• extrinsic to plasma membrane
Biological process	• signal transduction • positive regulation of binding • cellular response to acid
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6281 20194 Ensembl ENSG00000197747 ENSMUSG00000041959 UniProt P60903 P08207 RefSeq (mRNA) NM_002966 NM_009112 RefSeq (protein) NP_002957 NP_033138 Location (UCSC) Chr 1:
151.96 – 151.97 Mb Chr 3:
93.56 – 93.56 Mb PubMed search

S100-A10, also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. S100-A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.

The p11 protein is linked with the transport of neurotransmitters. Found in the brain of humans and other mammals, it has been implicated in the regulation of mood. In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy.