RYR or RyR may refer to
- Ryanodine receptor, a class of intracellular calcium channels
- Ryanair (ICAO callsign "RYR"), an Irish low cost airline
- Ryan International Airlines, a cargo company unrelated to Ryanair
- Ryde St John's Road railway station
- Robert Yates Racing, a NASCAR NEXTEL Cup and Busch Series racing team