Background
Ryan Wolfe, a former patrol officer, is hired after veteran CSI Tim Speedle is killed on the job. He has a strong background in science, having majored in chemistry at Boston College and now pursuing a master's degree in genetics. His master's degree takes a back seat to his job; he graduated top of his class at the police academy, well on his way to a promotion.
He catches the attention of CSI Lieutenant Horatio Caine at the scene of a bus crash. He showed great attention to detail and to the care of his sidearm, a Beretta 92, reflecting the fixation on minute details emerging from his obsessive-compulsive disorder. His eye for detail won Caine's respect, since poor gun maintenance led to the misfire at a critical moment that contributed to Wolfe's predecessor, Tim Speedle's tragic death in the Season 3 opener.
He is left-handed as seen in the episode, "Sex and Taxes". In season 7, episode 6 it is revealed that Ryan is afraid of heights. On the Stoned Cold episode, in which a victim was a school bully, he revealed to Eric Delko that he was bullied as a child which resulted in the damage of a telescope that he has saved up on his allowance for. Later, he was surprised by a new telescope in his locker while his colleagues teased him about the story.
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