Rufinus may refer to:
- Saints Rufinus, eleven saints named Rufinus in Roman Martyrology
- Rufinus of Assisi, 3rd century saint and martyr
- Rufinus (French saint) (d. 287), Christian martyr
- Rufinus (Roman governor), 3rd century governor of Roman Britain
- Rufinus (consul) (c. 335-395), Eastern Roman statesman
- Tyrannius Rufinus (c. 340-410), Roman monk, historian, and translator
- Saint Rufinus of Sarsina (5th century), bishop of Sarsina
- Rufinus (poet) of the Greek Anthology
- Rufinus (decretist), 12th-century canon lawyer