RPS6KA5

RPS6KA5

Identifiers Symbols RPS6KA5; MSK1; MSPK1; RLPK External IDs OMIM: 603607 MGI: 1920336 HomoloGene: 48302 ChEMBL: 4237 GeneCards: RPS6KA5 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding
Cellular component	• nucleus • nucleoplasm • cytoplasm
Biological process	• negative regulation of cytokine production • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • regulation of transcription, DNA-dependent • protein phosphorylation • response to stress • inflammatory response • epidermal growth factor receptor signaling pathway • intracellular protein kinase cascade • axon guidance • response to external stimulus • histone phosphorylation • positive regulation of CREB transcription factor activity • positive regulation of histone phosphorylation • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • positive regulation of histone acetylation • TRIF-dependent toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • histone H3-S10 phosphorylation • histone H3-S28 phosphorylation • histone H2A-S1 phosphorylation • innate immune response • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • neurotrophin TRK receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • interleukin-1-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9252 73086 Ensembl ENSG00000100784 ENSMUSG00000021180 UniProt O75582 Q8C050 RefSeq (mRNA) NM_004755 NM_153587 RefSeq (protein) NP_004746 NP_705815 Location (UCSC) Chr 14:
91.34 – 91.53 Mb Chr 12:
100.55 – 100.73 Mb PubMed search

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.