RNase L

RNase L

Identifiers Symbols RNASEL; PRCA1; RNS4 External IDs OMIM: 180435 MGI: 1098272 HomoloGene: 8040 ChEMBL: 3575 GeneCards: RNASEL Gene EC number 3.1.26.-, 3.1.27.-

Gene Ontology
Molecular function	• RNA binding • endoribonuclease activity • protein kinase activity • ATP binding • metal ion binding
Cellular component	• cellular_component • mitochondrion • cytosol
Biological process	• mRNA processing • protein phosphorylation • cytokine-mediated signaling pathway • negative regulation of viral genome replication • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6041 24014 Ensembl ENSG00000135828 ENSMUSG00000066800 UniProt Q05823 Q05921 RefSeq (mRNA) NM_021133 NM_011882 RefSeq (protein) NP_066956 NP_036012 Location (UCSC) Chr 1:
182.54 – 182.56 Mb Chr 1:
153.75 – 153.76 Mb PubMed search

Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2-5A-dependent ribonuclease — is an interferon-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene.

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons.