By Drainage Basin
This list is arranged by drainage basin, from north to south, with respective tributaries indented under each larger stream's name. All rivers in South Carolina drain to the Atlantic Ocean.
- Little River
- Pee Dee River
- Sampit River
- Black River
- Black Mingo Creek
- Pocotaligo River
- Little Pee Dee River
- Lumber River
- Lynches River
- Little River
- Jeffries Creek
- Black Creek
- Santee River (North Santee River and South Santee River are distributaries)
- Little River
- Wateree River
- Catawba River
- Fishing Creek
- Catawba River
- Congaree River
- Broad River
- Little River
- Enoree River
- Tyger River
- Fairforest Creek
- North Tyger River
- Middle Tyger River
- South Tyger River
- Sandy River
- Little Sandy River
- Pacolet River
- Lawsons Fork Creek
- North Pacolet River
- South Pacolet River
- Saluda River
- Little Saluda River
- Bush River
- Little River
- Reedy River
- North Saluda River
- South Saluda River
- Oolenoy River
- Gills Creek
- Broad River
- Wando River
- Cooper River
- Back River
- Ashley River
- Stono River
- Kiawah River
- Edisto River (North Edisto River and South Edisto River are distributaries)
- Four Holes Swamp
- North Fork Edisto River
- South Fork Edisto River
- Little River
- Ashepoo River
- Combahee River
- Little Salkehatchie River
- Salkehatchie River
- Coosaw River
- Morgan River (SC)
- Story River
- Beaufort River
- Broad River
- Colleton River
- Pocotaligo River
- Coosawhatchie River
- May River
- New River
- Wright River
- Savannah River
- Stevens Creek
- Little River
- Rocky River
- Seneca River
- Keowee River
- Little River
- Flat Shoals River
- Toxaway River
- Horsepasture River
- Whitewater River
- Thompson River
- Little River
- Keowee River
- Tugaloo River
- Chauga River
- Chattooga River
- East Fork Chattooga River
Read more about this topic: Rivers Of South Carolina