Rita Levi-Montalcini - Professional Life

Professional Life

During World War II, Levi-Montalcini conducted experiments from a home laboratory, studying the growth of nerve fibers in chicken embryos which laid the groundwork for much of her later research. (She describes this experience decades later in the 1995 science documentary Death by Design/The Life and Times of Life and Times, which also features her identical twin sister Paola, who had entered a decades-long career in the arts.) Her first genetics laboratory was in her bedroom at her home. In 1943, her family fled south to Florence, and she set up a laboratory there also. Her family returned to Turin in 1945.

In September 1946, Levi-Montalcini accepted an invitation to Washington University in St. Louis, under the supervision of Professor Viktor Hamburger. Although the initial invitation was for one semester, she stayed for thirty years. It was there that she did her most important work: isolating the nerve growth factor (NGF) from observations of certain cancerous tissues that cause extremely rapid growth of nerve cells in 1952. She was made a Full Professor in 1958, and in 1962, established a research unit in Rome, dividing the rest of her time between there and St. Louis.

From 1961 to 1969 she directed the Research Center of Neurobiology of the CNR (Rome), and from 1969 to 1978 the Laboratory of Cellular Biology.

Rita Levi-Montalcini founded the European Brain Research Institute, covering the appointment of president. Her role in this institute was at the center of some criticism from some parts of the scientific community in 2010.

Controversies were raised about the collaboration of Prof. Montalcini with the Italian Pharmaceutical Factory Fidia. Since 1975 the scientist promoted the drug Cronassial produced by Fidia from bovine brain. The drug turned out some years later to be able to cause a severe neurological syndrome (Guillain-Barré syndrome). For this reason Germany banned Cronassial in 1983, followed by other countries. Italy prohibited the drug only in 1993. In light of this episode serious criticism was levied at Levi-Montalcini.