Richard I. Morimoto - Significant Papers

Significant Papers

  • van Oosten-Hawle, P., R. Porter, and R. I. Morimoto. Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling. Cell 153: 1366-1378, DOI:10.1016 (2013).
  • Kirstein-Miles, J., A. Scior, E. Duerling, and R.I. Morimoto. The Nascent Polypeptide Associated Complex is a Key Regulator of Proteostasis. The EMBO Journal PMID 23604074 DOI: 10.1038 (2013).
  • Guisbert, E., D. M. Czyz, K. Richter, P. D. McMullen, and R. I. Morimoto. Identification of a Tissue-Selective Heat Shock Response Regulatory Network. PLoS Genetics 9(4): DOI: 10.1371 (2013).
  • Krammer, C., K.W. Park, L. Li, R. Melki, and R.I. Morimoto. Spreading of a Prion Domain from Cell to Cell by Vesicular Transport in C. elegans. PLoS Genetics 9(3): DOI: 10.1371 (2013).
  • Ciryam, C., R. I. Morimoto, M. Vendruscolo, C. M. Dobson, and E. P. O’Brien. In vivo Translation Rates can Substantially Delay the Co-Translational Folding of the E. coli Cytosolic Proteome. Proc. Nat. Acad. Sci. USA 110: E132-140, PMID 23256155 (2013).
  • Rampelt, H., J. Kirstein-Miles, S. Scholz, N. Nillegoda, R.I. Morimoto, B. Bukau. Metazoan Hsp70 Machines use Hsp110 to Power Protein Disaggregation. The EMBO Journal 31(21): 4221-35. PMID 22990239 (2012).
  • Morimoto, R.I. The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease. Cold Spring Harbor Symposia on Quantitative Biology Volume LXXVI: Metabolism and Disease. Cold Spring Harbor Press, p. 91-99, PMID 22371371 (2012).
  • Silva, M. C., S. Fox, H. Thakkar, M. J. Rivera Beam, M. D. Amaral, and R.I. Morimoto. A Genetic Screening Strategy Identifies Novel Global Regulators of the Proteostasis Network. PloS Genetics.7(12): (2011).
  • Calamini, B., C. Silva, F. Madoux, D. M. Hutt, S. Khanna, M. Chalfant, P. Hodder, B. Tait, D. Garza, W. Balch, and R.I. Morimoto. Small Molecule Proteostasis Regulators for Protein Conformational Disease. Nature Chemical Biology (2011).
  • Teixeira-Castro, A., M. Ailion, A. Jalles, H. R. Brignull, J. L. Vilaça, N. Dias, P. Rodrigues, J. F. Oliveira, A. Neves-Carvalho, R. I. Morimoto, and P. Maciel. Neuron-Specific Proteotoxicity of Mutant Ataxin-3 in C. elegans: Rescue by the DAF-16 and HSF1 Pathways. Human Molecular Genetics 20(15): 2996-3009, PMID 21546381 (2011).
  • Prahlad, V. and R.I. Morimoto. Neuronal Circuitry Regulates the Response of C. elegans to Misfolded Proteins. Proc. Natl. Acad. Sci. U.S.A. 108: 14204-14209, PMID 1106557108 (2011).
  • Gidalevitz, T., V. Prahlad, and R. I. Morimoto. The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms. Cold Spring Harbor Perspectives in Biology, 3: PMID 21536706 (2011).
  • Åkerfelt, M., R.I. Morimoto, and L. Sistonen. Heat Shock Factors: Integrators of Cell Stress, Development, and Lifespan. Nature Reviews Molecular Cell Biology, 11: 545-555 (2010).
  • Ben-Zvi-A., E.A. Miller, and R.I. Morimoto. The Collapse of Proteostasis Represents an Early Molecular Event in C. elegans Aging. Proc. Natl. Acad. Sci. USA. 106: 14914-14919 (2009).
  • Powers, E.T., R.I. Morimoto, A. Dillin, J.W. Kelly, and W.E. Balch. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Reviews of Biochemistry 78: 959-991 (2009).
  • Westerheide, S.D., J. Anckar, S. Stevens, L. Sistonen, and R.I. Morimoto. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1. Science 323: 1063-1066 (2009).
  • Prahlad, V., T. Cornelius and R.I. Morimoto. Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons. Science 320: 811-814 (2008).
  • Balch, W. E., R.I. Morimoto, A. Dillin, and J. W. Kelly. Adapting Proteostasis for Disease Intervention. Science 319: 916-919 (2008).
  • Morimoto, R.I. Proteotoxic Stress and Inducible Chaperone Networks in Neurodegenerative Disease and Aging. Genes and Development 22: 1427-1438 (2008).
  • Garcia, S., M.O. Casanueva, C. Silva, M. Amaral, and R.I. Morimoto. Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells. Genes and Development: 21: 3006-3016 (2007).
  • Brignull, H., F. Moore, S. Tang and R.I. Morimoto. Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal C. elegans Model. J. Neuroscience 26: 7597-7606 (2006).
  • Gidalevitz, T., A. Ben-Zvi, K. Ho, H. Brignull and R.I. Morimoto. Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases . Science 311: 1471-1474 (2006).
  • Holmberg, C., K. Staniszewski, K. Mensah, A. Chavez, A. Matouschek, and R.I. Morimoto. Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome. EMBO Journal 23: 4307-4318 (2004).
  • Morley, J.F. and R.I. Morimoto. Regulation of Longevity in C. elegans by Heat Shock Factor and Molecular Chaperones. Mol. Biol. Cell 15: 657-664 (2004).
  • Morimoto, R.I. Dynamic Remodeling of Transcription Complexes by Molecular Chaperones. Cell 110: 281-284 (2002).
  • Kim, S., E.A.A. Nollen, K. Kitagawa, V. Bindokas and R.I. Morimoto. Polyglutamine Protein Aggregates are Dynamic. Nature Cell Biology 4: 826-831 (2002).
  • Morley J.F., Brignull H.R., Weyers J.J. and R.I. Morimoto. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002).
  • Shen, X., R.E. Ellis, K. Lee, C.-Y. Liu, K. Yang, A. Solomon, H. Yoshida, R. Morimoto, D.M. Kurnit, K. Mori and R.J. Kaufman. Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development. Cell 107: 893-903 (2001).
  • Song, J., M. Takeda, and R.I. Morimoto. Hsp70-Bag1 Complex Mediates a Physiological Stress Signaling Pathway that Regulates Raf-1/Erk and Cell Growth. Nature Cell Biology 3: 276-282 (2001).
  • Thress, K., J. Song, R.I. Morimoto and S. Kornbluth. Reversible Inhibition of Hsp70 Chaperone Function by Scythe and Reaper. EMBO Journal 20: 103-1041 (2001).
  • Satyal, S., E. Schmidt, K. Kitagawa, N. Sondheimer, S. Lindquist and R.I. Morimoto. Polyglutamine Aggregates Alter Protein Folding Homeostasis in C. elegans. Proc. Natl. Acad. Sci. USA. 97: 5750-5755 (2000).
  • Shi, Y. D. Mosser and R.I. Morimoto. Molecular Chaperones as HSF1 Specific Transcriptional Repressors. Genes and Development 12: 654-666 (1998).
  • Morimoto, R.I. Regulation of the Heat Shock Transcriptional Response: Crosstalk between a Family of Heat Shock Factors, Molecular Chaperones, and Negative Regulators. Genes and Development 12: 3788-3796 (1998).
  • Kanei-Ishii C. Tanikawa J. Nakai A. Morimoto R.I. and S. Ishii. Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science. 277(5323):246-8, 1997.
  • Freeman, B.C., D. Toft and R.I. Morimoto. Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin CyP-40 and the Steroid Aporeceptor Associated Protein p23. Science 274: 1718-1720 (1996).
  • Freeman, B.C. and R.I. Morimoto. The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native Protein and Protein Refolding. EMBO Journal 15: 2969-2979 (1996).
  • Lee, B., J. Chen, D. Jurivich, C. Angelidis and R.I. Morimoto. Pharmacological Modulation of the Heat Shock Factor Activity by Anti-Inflammatory Drugs Protects Against Stress-Induced Cellular Damage. Proc. Natl. Acad. Sci. USA 92: 7207-7211 (1995).
  • Abravaya, K., M. Myers, S. Murphy and R.I. Morimoto. Human Heat Shock Protein HSP70 Interacts with HSF, the Transcription Factor That Regulates Heat Shock Gene Expression. Genes and Development 6, 1153-1164 (1992).
  • Jurivich, D., L. Sistonen, R. Kroes and R.I. Morimoto. Effects of Sodium Salicylate on the Human Heat Shock Response. Science 255, 1243-1245 (1992).
  • Abravaya K., Phillips B. and R.I. Morimoto. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Development. 5(11):2117-27, 1991.
  • Sarge, K., V. Zimarino, K. Holm, C. Wu and R.I. Morimoto. Cloning and Characterization of Two Mouse Heat Shock Transcription Factors with Distinct Inducible and Constitutive DNA Binding Ability. Genes and Development 5, 1902-1911 (1991).
  • Wu, B., C. Hunt and R.I. Morimoto. The Structure and Expression of the Human Gene Encoding the Major Heat Shock Protein HSP70. Mol. Cell. Biol. 5, 330-341 (1985).

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