Ribosome Shunting - Ribosome Shunting in Sendai Virus

Ribosome Shunting in Sendai Virus

Sendai virus Y proteins are initiated by ribosome shunting. Among 8 primary translation products of Sendai virus P/C mRNA, leaky scanning accounts for translation of protein C’, P, and C proteins, while expression of protein Y1 and Y2 is initiated via a ribosomal shunt discontinuous scanning. Scanning complex enters 5’ cap and scan ~50 nt of 5’ UTR, and then is transferred to an acceptor site at or close the Y initiation codons. In the case of Sendai virus, no specific donor site sequences are required.