Riboflavin - Mechanism of Action As Cofactors and Flavoproteins

Mechanism of Action As Cofactors and Flavoproteins

Flavoproteins exhibit a wide range of redox potential and therefore can play a wide variety of roles in intermediary metabolism. Some of these roles are:

  • Flavoproteins play very important roles in the electron transport chain
  • Decarboxylation of pyruvate and α-ketoglutarate requires FAD
  • Fatty acyl CoA dehydrogenase requires FAD in fatty acid oxidation
  • FAD is required to the production of pyridoxic acid from pyridoxal (vitamin B6)
  • The primary coenzyme form of vitamin B6 (pyridoxal phosphate) is FMN dependent
  • FAD is required to convert retinal (vitamin A) to retinoic acid
  • Synthesis of an active form of folate (5-methyl THF) is FADH2 dependent
  • FAD is required to convert tryptophan to niacin (vitamin B3)
  • Reduction of the oxidized form of glutathione (GSSG) to its reduced form (GSH) is also FAD dependent

Read more about this topic:  Riboflavin

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