Ribbon Synapse - Structure - Structural Plasticity

Structural Plasticity

In correspondence to its activity, ribbon synapses can have synaptic ribbons that vary in size. In mouse photoreceptor synapses when the neurotransmitter release rate is high and exocytosis is high, the synaptic ribbons are long. When neurotransmitter release rate is low and exocytosis is low, the synaptic ribbons are short. This has been identified with RIBEYE with the current hypothesis being that synaptic ribbons can enlarge by the addition of more RIBEYE subunit. RIBEYE interactions are required to form a scaffold formation protein of the synaptic ribbon.

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