Reverse triiodothyronine (3,3',5'-Triiodothyronine, reverse T3, or rT3) is a molecule that is an isomer of triiodothyronine (T3). Like T3, it is derived from thyroxine (T4).
rT3 increases in conditions such as sick euthyroid syndrome. rT3 is an inactive form of thyroid hormone. It increases in sick euthyroid syndrome because its clearance decreases while its production stays the same. The decreased clearance is possibly from lower 5'-deiodinase activity in the peripheral tissue or decreased liver uptake of rT3.
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