RERE

RERE

Identifiers Symbols RERE; ARG; ARP; ATN1L; DNB1 External IDs OMIM: 605226 MGI: 2683486 HomoloGene: 8101 GeneCards: RERE Gene

Gene Ontology
Molecular function	• chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • poly-glutamine tract binding • zinc ion binding • sequence-specific DNA binding
Cellular component	• histone deacetylase complex • nucleus • nucleolus • mitochondrion
Biological process	• chromatin remodeling • transcription, DNA-dependent • NLS-bearing substrate import into nucleus • multicellular organismal development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 473 68703 Ensembl ENSG00000142599 ENSMUSG00000039852 UniProt Q9P2R6 Q80TZ9 RefSeq (mRNA) NM_001042681 NM_001085492 RefSeq (protein) NP_001036146 NP_001078961 Location (UCSC) Chr 1:
8.41 – 8.88 Mb Chr 4:
150.28 – 150.62 Mb PubMed search

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.