Modification of DNA
In eukaryotes, the accessibility of large regions of DNA can depend on its chromatin structure, which can be altered as a result of histone modifications directed by DNA methylation, ncRNA, or DNA-binding protein. Hence these modifications may up or down regulate the expression of gene. Certain of these modifications that regulate gene expression are inheritable and are referred to as epigenetic regulation.
Read more about this topic: Regulation Of Gene Expression
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—William Gibson (b. 1948)