RDS may refer to:
- Amazon Relational Database Service, Amazon's cloud-based Relational Database Service
- Radio Data System
- Radio Dimensione Suono, an Italian radio station
- Random dot stereogram, a form of 3-D image
- SAP Rapid Deployment Solutions, from SAP AG
- Rate-determining step, the slowest step of a chemical reaction
- Rajolibanda Diversion Scheme - An Irrigation project in Mahbubunagar district, AP, India
- RDS-1, RDS-4, RDS-37 etc., nuclear bombs of the Sowiet Union, see Soviet atomic bomb project#Important Soviet nuclear tests
- Realistic disaster scenario
- Real-time data store
- Red dot sight, type of firearm reflector sight that uses a red light emitting diode to generate a red aiming dot
- Reddish South railway station, England has the National Rail station code RDS
- Reflectance Difference Spectroscopy
- Reliable Datagram Sockets, a computer network protocol used in Oracle RAC clusters
- Reliable Digit Span Score, a test used by mental health professionals to determine malingering or symptom exaggeration in cognitive functioning, with a score of 7 or below indicating positive findings.
- Remote Data Services, a deprecated component of Microsoft Data Access Components
- Remote Desktop Services, Microsoft's mechanism for remote access to applications and data on a remote computer over a network (formerly Terminal Services)
- Resolver Discovery Service (see RFC 2276)
- Research Defence Society
- Réseau des sports, a French-language television network in Canada
- RDS Info, a sister sports news channel to Réseau des sports
- Respiratory distress syndrome
- Retinal Degeneration, Slow, another name for the human gene Peripherin 2
- Reward Deficiency Syndrome, a term coined by neuro-scientist Dr Kenneth Blum upon discovering the addiction gene
- Romania Data Systems, an ISP in Romania
- Rough Draft Studios
- Royal Dublin Society
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- RDS Arena a stadium within the grounds of the Royal Dublin Society and home to Leinster Rugby
- Royal Dutch Shell
- Run Drop Slide
- RDS, a song by Alastair Galbraith