RDC may refer to:
- Residual dipolar coupling, a measurand in NMR-spectroscopy
- Budd Rail Diesel Car
- Railroad Development Corporation, an operator of railroads
- Central African Democratic Rally (Rassemblement Démocratique Centrafricain)
- Red Deer College
- Redditch railway station
- Regional Development Corporation
- Remote Desktop Connection
- Remote Differential Compression, a distributed file synchronization technology introduced with Windows Server 2003 R2 and Windows Vista
- Representative Democratic Council
- Research & Development Corporation Newfoundland and Labrador
- Rural District Council
- Democratic Republic of the Congo (La République Democratique du Congo), a country in Africa
- Recruit Division Commander, a drill instructor for the United States Navy
- Remote deposit capture, an electronic banking technology
- Research Diagnostic Criteria