Putative Health Effects
Although products containing this compound are marketed for weight loss, there is no clinical evidence for this effect in humans. The average estimated daily intake of dietary raspberry ketone has been estimated to be 0.42 mg/kg/day. Early studies in rats looking into the potential toxicity of raspberry ketone found no effects on the body weight of rats with doses up to 100 mg/kg, 238 times greater than the estimated intake for humans or 0.01% of body weight. A more recent study demonstrated that when mice were fed very high doses of raspberry ketone, up to 20 g/kg, 2% of body weight or 4761 times greater than estimated human intake, there was a statistically significant prevention of high-fat-diet-induced elevation in body weight. The high dose effect is reported to stem from the alteration of lipid metabolism, increasing norepinephrine-induced lipolysis and fatty acid oxidation in cultured adipocytes.
Nutritional supplement manufacturer Andrew Lessman criticized and countered sensationalized media and marketing claims about raspberry ketone’s purported weight-loss benefits and strongly cautioned against its use.
Read more about this topic: Raspberry Ketone
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