Raphe Nuclei - Anatomy

Anatomy

The raphe nuclei are traditionally considered to be the medial portion of the reticular formation, and they appear as a ridge of cells in the center and most medial portion of the brain stem.

In order from caudal to rostral, the raphe nuclei are known as the nucleus raphe obscurus, the raphe magnus, the raphe pontis, the raphe pallidus, the nucleus centralis superior, nucleus raphe dorsalis, nuclei linearis intermedius and linearis rostralis. Some scientists chose to group the linearis nuclei into one nucleus, shrinking the number of raphe to seven, e.g., NeuroNames makes the following ordering:

  • Raphe nuclei of medulla
    • Nucleus raphe obscurus (nucleus raphe obscurus)
    • Nucleus raphe magnus (raphe magnus)
    • Nucleus pallidus (raphe pallidus)
  • Raphe nuclei of the pontine reticular formation
    • Pontine raphe nucleus (raphe pontis)
    • Inferior central nucleus
  • Raphe nuclei of the midbrain reticular formation
    • Superior central nucleus (nucleus centralis superior, or median raphe nucleus)
    • Dorsal raphe nucleus (nucleus raphe dorsalis)

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