Ralph Assheton may refer to:
- Ralph de Ashton, or Sir Ralph Assheton (fl. 1421-1486), 15th century nobleman, also known as 'The Black Knight'
- Ralph Assheton (died 1559), MP for Liverpool (UK Parliament constituency)
- Ralph Assheton (general) (1596 – 17 February 1650), MP for Lancashire, 1640
- Sir Ralph Assheton, 2nd Baronet, of Lever (c. 1605-1680), MP for Clitheroe 1625, 1626, 1640–1653, 1659–1662, 1679–1680
- Sir Ralph Assheton, 2nd Baronet, of Middleton (11 Feb 1652–4 May 1716), MP for Liverpool 1677 and Lancashire 1694, 1695
- Ralph Assheton (1830–1907), MP for Clitheroe 1868–1880
- Sir Ralph Cokayne Assheton, 1st Baronet (1860–1955)
- His son Ralph Assheton, 1st Baron Clitheroe (1901–1984), Conservative Party politician and MP
- Ralph Assheton, 2nd Baron Clitheroe (born 1929 as Ralph John Assheton)
It may also refer to one of their many ancestors named Ralph Assheton: see Assheton baronets