RAGE Ligands
RAGE is able to bind several ligands and therefore is referred to as a pattern-recognition receptor. Ligands which have so far been found to bind RAGE are:
- AGE
- HMGB1 (Amphoterin)
- S100b
- S100A7 (psoriasin) but not highly homologous S100A15 (koebnerisin)
- S100P
- Amyloid-β-protein
- Mac-1
- Phosphatidylserine.
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