Entertainment
- R2: Reign of Revolution, an online game
- R2 (Rock'n'Reel), a British music magazine
- R2-D2, a character from Star Wars films and books
- R2 unit, a line of droids in the fictional Star Wars universe
- Code Geass: Lelouch of the Rebellion R2, a 2008 anime series
- Resistance 2, a video game
- Relapse 2, a 2009 album by rapper Eminem
- Patricio Rey y sus Redonditos de Ricota or R2, an Argentine rock band
- Timepass by Rashmi Ranjan or R2
- A button on the PlayStation 3 controller and playstation 2controller
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