Generations
Researchers divide the quinolones into generations based on their antibacterial spectrum. The earlier-generation agents are, in general, more narrow-spectrum than the later ones, but no standard is employed to determine which drug belongs to which generation. The only universal standard applied is the grouping of the nonfluorinated drugs found within this class (quinolones) within the 'first-generation' heading. As such, a wide variation exists within the literature dependent upon the methods employed by the authors.
- Some researchers group these drugs by patent dates
- Some by a specific decade (i.e., '60s, '70s, '80s, etc.)
- Others by the various structural changes
The first generation is rarely used today. Nalidixic acid was added to the OEHHA Prop 65 list as a carcinogen on 15 May 1998. A number of the second-, third-, and fourth-generation drugs have been removed from clinical practice due to severe toxicity issues or discontinued by their manufacturers. The drugs most frequently prescribed today consist of Avelox (moxifloxacin), Cipro (ciprofloxacin), Levaquin (levofloxacin), and, to some extent, their generic equivalents.
Read more about this topic: Quinolone Antibiotics
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“Shoals of corpses shall witness, mute, even to generations to come, before the eyes of men that we ought never, being mortal, to cast our sights too high.”
—Aeschylus (525–456 B.C.)
“Frankly, I do not like the idea of conversations to define the term “unconditional surrender.” ... The German people can have dinned into their ears what I said in my Christmas Eve speech—in effect, that we have no thought of destroying the German people and that we want them to live through the generations like other European peoples on condition, of course, that they get rid of their present philosophy of conquest.”
—Franklin D. Roosevelt (1882–1945)
“Parenthood has really changed for me. It’s much more than taking care of my son; more than saying yes and no. Now I have to figure out what I think and what I know so that I can answer his questions and explain things to him.”
—Anonymous Parent. As quoted in Between Generations by Ellen Galinsky, ch. 4 (1981)