- Abigail Adams - Wife of John Adams, second President of the United States
- Abigail "Nabby" Adams Smith, daughter of Abigail and John
- Brooks Adams - noted historian
- Charles Francis Adams, Sr.
- Charles Francis Adams, Jr. - Civil War general, president of Union Pacific Railroad (1884–1890)
- Charles Francis Adams III - 44th Secretary of the Navy, mayor of Quincy
- Charles Adams (1770–1800)
- John Adams - Second President of the United States, first Vice-President
- John Quincy Adams - Sixth President of the United States
- John Quincy Adams II - lawyer and politician
- Thomas Boylston Adams - Massachusetts Representative, justice
- Paul W. Airey - First Chief Master Sergeant of the Air Force
- Carl Andre - minimalist artist
- Jennie E. Crocker - First woman Master Mariner
- Henry Beston - writer and naturalist
- John Cheever - novelist
- Dick Dale - musician
- Bill Dana - comedian (famous as Jose Jiminez)
- William Delahunt - U.S. congressman for the 10th District
- Joseph Dunford - four-star general, Assistant Commandant of the Marine Corps
- Billy DeWolfe - actor
- Ruth Gordon - actress
- John Hancock - patriot and president of the Continental Congress
- Howard Deering Johnson - founder of the Howard Johnson's chain
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- John F. Keenan - Massachusetts State Senator from the Norfolk and Plymouth district.
- Pete Kendall - Offensive Lineman for the Washington Redskins
- Jake Kilrain - Champion, Bare Knuckles Boxer (February 9, 1859 – December 22, 1937)
- Adolph "Jazz" Maffie - bookie and participant in the Great Brink's Robbery
- Francis Wayland Parker - educator
- Everett P. Pope - World War II Medal of Honor recipient
- Dorothy Quincy Hancock Scott
- Edmund Quincy (1628-1698), who built the Dorothy Quincy House (1685)
- Edmund Quincy (1681-1737), jurist
- Edmund Quincy (1703-1788)
- Josiah Quincy II - attorney, "the Patriot", newspaper propagandist
- Josiah Quincy III - president of Harvard University (1829–1845), U.S. Representative (1805–1813), mayor of Boston (1823–1828)
- Josiah Quincy, Jr. - mayor of Boston (1846–1848), built the Josiah Quincy Mansion
- Josiah Quincy - General Court representative, assistant secretary of the Navy, mayor of Boston (1895–1899)
- Samuel Miller Quincy - lawyer, historian, Civil War soldier, and 28th mayor of New Orleans (May 5, 1865 – June 8, 1865)
- Lee Remick - actress
- William B. Rice - industrialist and local philanthropist
- Wilbert Robinson - Baseball Hall of Fame player and manager
- Charles Sweeney - Air Force major general and the pilot for the Nagasaki nuclear attack
- Dropkick Murphys-Celtic punk rock band
- Mike Mottau -NHL Player Currently with the Boston Bruins
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