Quadruple may refer to:
- 4-Tuple, a mathematical structure consisting of a sequence of four elements
- Quadruple, a term for winning four association trophies
- Quad (figure skating), a figure skating jump
- Home run in baseball
- Quadruple-precision floating-point format in computing
- Quadruple Alliance (disambiguation), the name of a number of military alliances
- A multiple birth with four offspring