QKI

Identifiers Symbols QKI; Hqk; QK; QK1; QK3; hqkI External IDs OMIM: 609590 MGI: 97837 HomoloGene: 11059 GeneCards: QKI Gene

Gene Ontology
Molecular function	• RNA binding • protein binding • SH3 domain binding
Cellular component	• nucleus • cytoplasm
Biological process	• vasculogenesis • mRNA processing • regulation of translation • spermatid development • RNA splicing • positive regulation of gene expression • myelination • muscle cell differentiation • long-chain fatty acid biosynthetic process • mRNA transport
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9444 19317 Ensembl ENSG00000112531 ENSMUSG00000062078 UniProt Q8WY44 Q9QYS9 RefSeq (mRNA) NM_006775 NM_001159516 RefSeq (protein) NP_006766 NP_001152988 Location (UCSC) Chr 6:
163.84 – 164 Mb Chr 17:
10.21 – 10.32 Mb PubMed search

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 . Two more new members are KHDRBS3 and KHDRBS2.

The QKI gene is implicated as being important in schizophrenia, and QKI controls translation of many oligodendrocyte-related genes.