Pyruvate Dehydrogenase Kinase - Phosphorylation Sites

Phosphorylation Sites

PDK can phosphorylate a serine residue on pyruvate dehydrogenase at three possible sites. Some evidence has shown that phosphorylation at site 1 will nearly completely deactivate the enzyme while phosphorylation at sites 2 and 3 had only a small contribution to complex inactivation. Therefore, it is phosphorylation at site 1 that is responsible for pyruvate dehydrogenase deactivation.