Laboratory Synthesis
In addition to in vivo synthesis of purines in purine metabolism, purine can also be created artificially.
Purine (1) is obtained in good yield when formamide is heated in an open vessel at 170 °C for 28 hours.
This remarkable reaction and others like it have been discussed in the context of the origin of life.
Oro, Orgel and co-workers have shown that four molecules of HCN tetramerize to form diaminomaleodinitrile (12), which can be converted into almost all natural-occurring purines.
The Traube purine synthesis (1900) is a classic reaction (named after Wilhelm Traube) between an amine-substituted pyrimidine and formic acid.
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